Palliative care 2016

Opioid tolerance in advanced cancer patients

Open label multicenter study (Fen-Bel 5 study) compassionate use TTS-fentanyl in Belgium (59 physicians) Palliative untreatable cancer patients with a assessed life expectancy of ≥ 3 months that need opioids for pain relief could be included (inform. cons) After stabilisation (14d) on oral morphine è VAS-score <3,5 Change of morphine è equivalent dose TTS-fentanyl, oral morphine is free available for break through pain (BTP) Dose fentanyl is up-titrated if oral morphine ≥ 60mg/d for BT Aim of the study: compliance + side effects of TTS fentanyl