Palliative care 2016

2500

PCU Leuven N = 1088patients

< 60 mg OME/dag (N=156) 60 - 299 mg OME/dag (N=533) 300 - 599 mg OME/dag (N=156) 600 - 900 mg OME/dag (N=52) > 900 mg OME/dag (N=82)

2000

1500

1000

500

0

W-4

W-3

W-2

D-7

D-3 D-2 D-1

Mean OME dose (mg/day)

Time before daeth in weeks

Morphine, early provided in the disease trajectory, is not automatically leading to tolerance/addiction!!