Palliative care 2017
Controlled release morphine
• 8 hourly, 12 hourly or 24 hourly
• If switching from 4 hourly morphine start from same total 24 hour dose as immediate release morphine once dose requirements defined by titration • No loading dose required
• Ensure breakthrough morphine also available • Anticipate slow increase in morphine dose with time
• Median dose in advanced cancer 40-60mg 4 hourly
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