Particle Therapy 2017

Dosimetrical evidences

AUTHOR [Ref] (Year) Miralbell, R [18 ] (1997)

TOTAL DOSE (CGE) 30 Brain ± 10 ventricles

SITE / TUMOUR TYPE

RÉSULTS

Medulloblastoma (supra tentorial)

P: æ risk IQ decline

Miralbell, R [19 ] (1997)

Medulloblastoma (spine)

30

P: æ dose vertebral body, heart, liver, thyroid, gonads

Fuss, M [20 ] (1999)

Optic gliomas

50.4

P: k conformation large tumours, k protection chiasm, contralat ON, hypophysis, temporal lobes

Lin, R [21 ] (2000)

Posterior fossa

54

P k sparing cochlea, temporal lobes

Miralbell, R [22 ] (2000)

RMS orbit, NHL, meningiomas

30-54

IMPT: k sparing lens/cornea

Hug, EB [23 ] (2001)

Neuroblastoma

34.2

P: k sparing homolat/contralat kidneys, liver, spinal cord

Miralbell, R [18 ] (2002) St Clair WH [24 ] (2004)

Medulloblastoma, RMS PM

36-50

æ risk K2

Medulloblastoma

23 CS/54 PF

P: k sparing cochlea, hypophysis, heart…

Yuh, GE [25 ] (2004)

Medulloblastoma

36 CS/ 54 PF P

m dose cochlea, vertebrae, thorax, abdomen, m myelosuppression

Krengli, M [26 ] (2005)

Retinoblastoma

40 ± 6

P: k sparing orbit, Contralateral eye, brain, hypophysis

Lee, CT [ 27] (2005)

Medulloblastoma, 1, retinoblastoma, 2, pelvis3

23-54

P: k sparing1: cochlea, hypophysis; 2: orbit, lens; 3:ovaries, iliac bone

Merchant, TE [28] (2008)

Optic glioma 1,Ependymoma PF2, Medulloblastoma3, Craniopharyngioma4

Variable

P: k sparing 1,2 : temporal lobes, 3 :cochlea, 4 : æ risk IQ decline