Particle Therapy 2017

0 RADCOMP

Hypothesis: Early increases in circulating biomarkers will differ according to RT; photon therapy will result in a more adverse biomarker profile. Biologic Alteration Biomarker Inflammation GDF-15, hsCRP Microvascular Dysfunction PlGF Oxidative Stress MPO, PON, Aryl Myocyte Injury TnT Myocyte Stress NT-proBNP Fibrosis Galectin-3

CONSORTIUM Aim 1: Insight into Biologic Mechanisms

● Specific Aim 1: To determine the early changes in multiple biomarkers in patients undergoing RT, and how these changes differ in proton versus photon therapy.