Particle Therapy 2017

PROs Q3 mo

Q3 mo

Follow-up

Follow-up

PROs

Surgery

No Surgery

Frank – PI

Trial Activated – Sept 2013

Restaging

Recovery 10 wks

IMRT (70 Gy)

IMPT (70 Gy(RBE))

PROs

Chemotherapy (locally advanced disease) Treatment 33 days

Chemotherapy (locally advanced disease)

I

I

R

A

N

D

O

M

Z

A

T

O

N

H-N Phase II/III Randomized Trial (MDACC) Oropharyngeal Cancer - IMPT vs IMRT

1) Stage III-IV

2) Squamous cell carcinoma

3) ECOG<2

4) Target volume delineation

Eligibility

oropharyngeal cancer

Primary endpoint: CTC-AE G3+ toxicity at 90 days – 2 years Courtesy Steve Frank