Particle Therapy 2017

Principles of the LEM (Scholz et al. Rad Env. Biophys. 1997)

Input parameters: • Particle spectrum • Radial Dose distribution:

1

c E r 

rD  )(

max

2

r

• Photon dose response

2

) DD e DS     (

) ( 

• Transition from LQ to linear survival at doses >1000Gy • Target size: cell nucleus

zyxdS )) , ,(( ln

 

N

dV



X

lethal

Nucleus

V

Nucleus