Particle Therapy 2017
Clonogenic survival
Late cell death Apoptosis, Necrosis
Vast majority of proliferating normal cells
Most tumor cells
Mitotic
catastrophe
Cell cycles
Multiple cell cycles
Apoptosis, Necrosis
Early cell death
Mitosis
Normal cells: lymphocytes, spermatogonia, intestinal cells, embryonal cells Tumors of haematopoetic origin
DNA
damage
response
Adopted from Wouters 2009 When and why cells die after irradiation ? senescence = cells cease to divide
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