Particle Therapy 2017

damage

sensors

signaling pathways second messengers, tyrosin phosphorylation effectors

e.g. repairosomes

ATM, ATR, SMG1

transducer

consequences

recognition

adapted from: Shilof Y, Nature Reviews, 2003

cell cycle cell survival cell death regulation

excessive damage, irrepairable

activation of the

cell death pathway

DNA lesions

ionizing radiation

DNA repair

survival response network cell cycle

regulation

activation of the amount and type of damage that can be handled

stress response Radiation damage registration & processing