Particle Therapy 2017

Repopulation of clonogenic tumor cells

Surviving cancer cells proliferate during the intervals between treatments and this process is an important cause of treatment failure.

TCD50 in head and neck tumors as a function of overall treatment time

Withers et al. Acta Oncol. 27: (1988)

When treatment time is extended beyond about 1 month , repopulation between dose fractions increases the number of tumor cells that must be killed.

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Bentzen and Thames 1991