Particle Therapy 2017

Radiation effects

cell cycle

delay in the movement of cells through cell cycle phases

activation of cell cycle checkpoints !

mainly normal cells

late G2 checkpoint: • dose dependent • applies to cells iradiated in G1 or S • affect radiosensitivity

Molecular Cell Biology Lodish H, Berk A, Zipursky SL, et al. New York: ; 2000.