Particle Therapy 2017

Indirect effects: stem cells Solid tumors are organized hierachically and is assumed that they contain a small population of self-renewing cancer stem cells

Cancer stem cells, especially in their quiescent state are considered radioresistant Many cancer stem cells are located in a perivascular niche and are supported by endothelial cells Hypofractionation preferentially destroys endothelial cells and may inadvertently eradicate cancer stem cells