Particle Therapy 2017

Macrophages Immunological “keyplayers”

➢ Cytotoxic T cells recognize Ag on CC and kills them ➢ Natural Killer Cells cri.cal to innate immune system Tumor cells down-regulate an.gens that cause them to be recognized

‘ M1 ’ produce reac.ve oxygen species (ROS) par.cipate in Th1 (T-helper cell) T cell mediated immunity responses and have an.-tumor ac.vity ‘ M2 ’ have different cell surface receptors, produce different cytokines and are more involved in .ssue remodeling + angiogenesis