Particle Therapy 2017

Normal tissue effects

Response to radiation

The response to radiation of tumors and normal proliferative tissues (responsible for acute reactions) substantially differs from that of normal late-responding tissues

Tumors and normal proliferative tssues : cell injury mechanism is largely regulated by coefficient α (lethal single-impact injury) Late responding normal tissues: coefficient β (lethal injury due to accumulation of sub-lethal injury) predominates