Particle Therapy 2017

Summary Hypofractionation

always associated with an escala/on in physical dose most features of the 5 R’s of conven/nal frac/ona/on are different ! vascular damage prominent at doses > 10 Gy leading to indirect cell death evidence for stem cell inac/va/on and differen/al immunological effects

due to its increased biological effec/veness high- LET intensifies the bioeffects of hypofrac/ona/on