Particle Therapy 2017

cell survival adhesion

migration NFkB

damage-inducible and

stress-related proteins reactive oxygen species (ROS)

cytokines for intercellular signaling

(TNF α, interleukin 1, 8, TGF ß)

Radiation-induced signals transmitted through existing pathways: No radiation-specific pathways ! Signaling in both directions ! death receptor Fas-R TRAIL-R apoptosis repair proliferation growth factors e.g. EGF inflammation immunity, survival cytokines e.g.TNF- alpha

Radiation-induced cell communication