Particle Therapy 2017

damage

sensors

signaling pathways second messengers, tyrosin phosphorylation effectors

e.g. repairosomes

ATM, ATR, SMG1

transducer

consequences

recognition

adapted from: Shilof Y, Nature Reviews, 2003

cell survival cell death

excessive damage, irrepairable

activation of the

cell death pathway

genetic

instability

low fidelity repair

DNA lesions

ionizing radiation

cell cycle regulation stress response DNA repair

survival response network

activation of the

amount and type of damage that can be handled

Radiation damage registration & processing