Particle Therapy 2017

RTOG 0617 Multivariate Cox Model Backwards Selection

Covariate

Comparison 60 Gy v 74 Gy Max grade ≥3 Continuous Continuous

HR (95% CI)

p-value

Radiation dose Esophagitis PTV (volume)

1.36 (1.06, 1.74) 1.48 (1.07, 2.05)

0.016 0.018 0.054 0.004

1.000 (1.000, 1.001) 1.006 (1.002, 1.011)

Heart V5

Two-sided log-rank p value. Backwards selection with p ≤0.10 staying criteria. Variables entering model: Radiation dose, age, histology, max related esophagitis grade, overall RT review, PTV, %PTV coverage, heart V5, lung V5, esophagus V20