Particle Therapy 2017

National Cancer Database: Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer Kristin A. Higgins et al. Emory University, Atlanta; Washington University, St. Louis, Missouri; University of Pennsylvania, Philadelphia; Penn State Hershey Cancer Institute, Pennsylvania;American University of Beirut, Lebanon. IJROBP, Volume 97 Number 1 2017 Data Base Query 2004-2012 for Stage I-IV NSCLC with Thoracic RT 243,822 patients analyzed: 243,474 photons 348 patient treated with protons Non-proton therapy was associated with significantly worse survival compared with proton therapy (hazard ratio 1.21 [95% CI 1.06-1.39]; P<.01). On propensity matched analysis, proton radiation therapy (nZ309) was associated with better 5-year overall survival 22% versus 16% . For stage II and III patients, non-proton radiation therapy was associated with worse survival compared with proton radiation therapy (hazard ratio 1.35 [95% CI 1.10-1.64], P<.01).

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