Particle Therapy 2017

Activation of pro-survival oncogenes (e.g. EGFR) Up-regulation of antioxidative enzymes (e.g. superoxide dismutase, catalase)

Human Ovarian Carcinoma

Mutated tumor suppressors (e.g. p53) Evading cell death (e.g. BCl2, Survivin)

DNA repair gene amplification

Inherent or acquired tumor cell resistance

Biological factors