Particle Therapy 2017

Toxicity reduction by protons (retrospective analysis)

NSCLC treated with radiation therapy + chemotherapy at M.D. Anderson(1,2)

3D CRT

IMRT 63 Gy

Protons 74 CGE

Dose

63 Gy

% patients stage IIIA-B22

87%

91%

87%

Toxicity Esophagitis – G3+ Pneumonitis – G3+

18% 30%

44%

5% 2%

9%

(1) Samir Sejpal et al., “Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer,” Cancer e-publication ahead of print (January 24, 2011): 1- 10 (2) Retrospective analysis. In lieu of selection criteria, percentage of patients with Stage IIIA-IIIB were summarized Note: Grade 3 and higher toxicities result in significant medical intervention including hospitalization to manage adverse side effects`

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