Particle Therapy 2017

Establishing Evidence-Based Indica3ons for Proton Therapy: An Overview of Current Clinical Trials

Mark V. Mishra, Univ. Maryland, IJROBP, 2017 (97)

➢ clinicaltrials.gov and the World Health Organiza3on Interna3onal Clinical Trials PlaSorm Registry. ➢ Total of 122 ac3ve PBT clinical trials iden3fied ➢ Target enrollment of >42,000 pa3ents worldwide. ➢ 96 trials (79%), classified as interven3onal studies. ➢ Observa3onal studies accounted for 21% of trials but 71% (n=29,852) of planned pa3ent enrollment. ➢ Most common: Gastrointes3nal tract tumors (21%, n=26), tumors of the central nervous system (15%, n=18), and prostate cancer (12%, n=15). ➢ 5 ac3ve studies (lung, esophagus, head and neck, prostate, breast) will randomize pa3ents between protons and photons, and 3 will randomize pa3ents between protons and carbon ion therapy.