Particle Therapy 2017

CNS: RTOG-1205: Recurrent GBM. Randomized phase III trial of concurrent bevacizumab and re - irradiation versus bevacizumab alone. Open. Permitting protons. Accrual 180 patients. Prescription: 35 Gy in 10 fractions. Randomization is between bevacizumab plus radiation versus bevacizumab alone, at the time of next recurrence re-irradiation will be permitted. NRG-BN001: Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma. Standard fractionation 60 Gy in 30 fractions versus dose-escalated, hypofractionation 75 Gy in 30 fractions. Hypothesis: prolonged overall survival from 16 months (standard Dose of 60 Gy) to 22 months Randomization between dose, not modality. However, modalities will be compared Accrual: 576 patients. Activated 10/2014 NRG: (Radiation Therapy Oncology Group – recently integrated into new organization “NRG” (= NASBP, RTOG, GOG): Note: Innova*ve concept to deal with difficul*es of true randomiza*on between protons and photons given referral reali*es and clinical urgency to start RT