Particle Therapy 2017

• Phase I/II trial. 20 women with T-1 breast Ca, neg. margins after lumpectomy • PTV: lumpectomy cavity plus 1.5-2.0 cm, minimum 5mm distance to surface/skin • 32 Gy(RBE) total dose: 4 Gy (RBE) B.I.D. over 4 days • 1-3 field arrangements overall, 1 field treated per day only • „Skin dose per field approached maximum dose“, Single field per day = Accelerated Partial-Breast Proton Therapy: Initial MGH Experience Kozak, Taghian et al. IJROBP 66(3):691, 2006

full 4 Gy skin dose. (MGH, passive scatttering ) • Observation: Median F/U 12 months (8-22) increased acute toxicity: 80% moderate to severe skin color changes 22% severe moist desquamation