Particle Therapy 2017

Risk of late toxicity as a function of radiation dose and volume

Dose (Gy) 0

20

40

60

70

0-20%

V O L U M E V O L U M E V O L U M E V O L U M E

20-40% 40-60% 60-80% 80-100% 0-20% 20-40% 40-60% 60-80% 80-100% 0-20% 20-40% 40-60% 60-80% 80-100% 0-20% 20-40% 40-60% 60-80% 80-100% 0-20%

Spinal cord

<1%

<5%

10-50%

Rubin, Constine, et al LENT scoring IJROBP 1995

<5%

<10%

<20%

>20%

Lun g

<5%

10-20%

30-50%

>75%

>50%

Heart

<5%

5-10%

10-25%

<5% Toxicity is a function of radiation dose! <15-20%

25-40%

10- 15%

15- 25%

25- 40%

>40%

Live r

<5%

<25%

<1%

5-25%

>75%

Kidne y

>50%