Particle Therapy 2017

Radiation damage registration & processing

adapted from: Shilof Y, Nature Reviews, 2003

ionizing radiation

damage recognition

sensors ATM, ATR, SMG1

DNA lesions

amount and type of damage that can be handled

excessive damage, irrepairable

transducer signaling pathways second messengers, tyrosin phosphorylation

activation of the survival response network

effectors e.g. repairosomes

DNA repair

cell death

cell survival