Particle Therapy 2017

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DNA repair: Non-homologeous endjoining (NHEJ) Double Strand Break (DBS)

Exposed ends of the DNA strands are detected by the KU70–KU80 heterodimer DNA-dependent protein kinase ( DNA-PKcs ) stabilize broken ends The heterodimer XRCC4/Ligase IV subsequently assists in repairing the break Fast repair, can be error-prone !!! Loss of complete sequences of bases possible