Particle Therapy 2017

When and why cells die after irradiation ?

Adopted from Wouters 2009

Cell cycles Multiple cell cycles

DNA damage response

Clonogenic survival

Mitotic catastrophe

Mitosis

senescence = cells cease to divide

Early cell death Apoptosis, Necrosis

Late cell death Apoptosis, Necrosis

Normal cells: lymphocytes, spermatogonia, intestinal cells, embryonal cells Tumors of haematopoetic origin

Vast majority of proliferating normal cells Most tumor cells