Particle Therapy 2017

Radiation-induced cell communication

Radiation-induced signals transmitted through existing pathways: No radiation-specific pathways ! Signaling in both directions ! death receptor Fas-R TRAIL-R growth factors e.g. EGF cytokines e.g.TNF- alpha

damage-inducible and stress-related proteins reactive oxygen species (ROS) cytokines for intercellular signaling (TNF α, interleukin 1, 8, TGF ß)

cell survival adhesion migration

repair proliferation

NFkB

apoptosis

inflammation immunity, survival