Particle Therapy 2017

Biological factors

Inherent or acquired tumor cell resistance

Human Ovarian Carcinoma

Mutated tumor suppressors (e.g. p53) DNA repair gene amplification

Activation of pro-survival oncogenes (e.g. EGFR) Up-regulation of antioxidative enzymes (e.g. superoxide dismutase, catalase) Evading cell death (e.g. BCl2, Survivin)