Physics Bucharest 2017
TARGIT clinical trials • Phase 3 RCT compared single 20Gy TARGIT with whole breast irradiation
• Over 3,500 patients recruited from 33 centres
• Entry if > 45 years and solitary cancer < 3.5cm diameter
• Additional EBRT given in 1 in 5 if histology more adverse (risk stratified approach)
• Recurrence 3.3% TARGIT vs. 1.3% EBRT
• Controversy about statistical analysis and interpretation
Vaidya et al. Lancet (2014) 383: 603-13
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