Physics Bucharest 2017
Clinical use of IMRT: What’s the evidence?
Improved dose distribution → clinical benefit?
Review 2012 on IMRT vs. non-IMRT :
3 RCT in LA-H&N (205 pts),
Evidence
61 comparative studies; only 6 RCT
3 RCT in breast cancer (1809 pts)
Primary endpoints: acute and late toxicity Not powered to detect differences in tumor control
Staffurth Clin Oncol 2010 De Neve Semin Radiat Oncol 2012
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