Physics Bucharest 2017
Head & Neck cancer
Scientific evidence: 4 RCT
Study
Organ
IMRT/ non-MRT
Primary endpoint Other endpoints Xerostomia ≥2 (2y) Acute fatigue 2y OS
IMRT Non- IMRT
p
Nutting 2011 (PARSPORT)
oropharynx hypopharynx
47/47
29% 74% 78%
83% 41% 76%
<0,001 0,002 NS
Kam 2007
nasopharynx
28/28
Xerostomia ≥2 (1y)
39% 82% 0,001
Evidence
Gupta 2012 Rathod 2013
oropharynx hypopharynx larynx
32/28
Acute xerostomia ≥2 Xerostomia ≥2 (2y) SC fibrosis (2y) 3y OS QOL
59% 23% 14% 71% better better better
89% 59% 56% 68%
0,003 0,02 0,005 NS <0,05 0,002 <0,001
Pow 2006
nasopharynx
46/50 Saliva flow QOL
(& comparative case studies)
28
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