Physics Bucharest 2017
Interplay effect: Lung cancer
Studies show that interplay effect can alter the dose distribution of a single fraction , but not a fractionated course of treatment. Dose variation (Jiang et al. )
1 fraction, 1 field: 30% 1 fraction, 5 fields: 18% 30 fractions: 1-2%
SABR : interplay effect is negligible , effects are averaged out due to • larger number of MU • increased treatment time
Potential risks: interplay effect
Strategies to reduce interplay effect: • ↑ n ° of arcs •
↓ dose rate prolonging treatment time • avoid MLC motion perpendicular to the tumor motion.
Chan JTO 2014, Jiang Phys Med Biol 2003
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