Physics Bucharest 2017

Brain metastasis

Radiosurgery +/- whole brain radiotherapy

SRS with or without WBRT in the treatment of patients with single of multiple brain metastases Randomized trials # BM Study endpoint SRS SRS+WBRT p Aoyama JAMA 2006 1-4 MS (months) 8 7.5 NS 1 year overall recurrence rate 76.4% 46.8% <0.001 Neurological death rate 19.3% 22.8% NS 1y KPS > 70 27% 34% NS EORTC 22952-26001 Kocher JCO 2011 1-3 Median OS (months) 10.7 10.9 NS 2y relapse at initial site 31% 19% 0.04 2y relapse at new intracranial site 48% 33% 0.02 2y Survival with functional independance 22.3% 22.6% NS

Clinical indications

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