Physics Bucharest 2017

Lung metastasis

Rusthoven JCO 2009

Hof Strahl Onk 2007

Hoyer Acta Oncol 2006

Nuyttens IJROBP 2015

Study

Phase I/II

Phase I/II

Phase II

Phase II

Inclusion

≤ 3 lesions, cum diam max 7cm Extrathoracic disease allowed if low burden…

Max 4 cm No other M+ site Inoperable

Max 6 cm Lung & liver Inoperable 1-4 mets Primary tu treated

Max 2 organs, 5 lesions, Metachronous, Primary controlled … 30 Gy /1 fr 60 Gy / 3 fr or 5 fr 56 Gy / 7 fr

Dose

48-60 Gy / 3fr

12-30 Gy / 1 fr (isocenter dose)

45 Gy / 3 fr

Pts/lesions

38/63

61/71

65/142

37/57

Toxicity grade 3 8% (3 pts)

5% (3 pts)

5 pts

Clinical indications

Median fup

15.4 months

14 months

4.3 years

36 months

2 y Local Control

96%

74%

86%

90% (3-7 fr) 75% (1 fr)

2 y OS

39%

65%

38%

63%

Primary

various

various

colorectal

Various (colorectal)

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