Physics Bucharest 2017

Liver metastasis: toxicity

Typical acute toxicity:

Study

Pts/ targets

Dose

Grade 3 hepatic toxicity

-Fatigue -Nausea -Abdominal pain -Fever -Liver enzymes -Erythema -Gastritis/oesophagitis/colitis

Herfarth JCO 2001

37/60 14-26 Gy/ 1fr

0

Kavanagh Acta Oncol 2006 Mendez-Romero Acta Oncol 2006

21/28 36-60 Gy / 3fr

0

17/34 37.5 Gy / 3 fr

2 pts

Katz IJROBP 2007

69/174 50 Gy / 5fr

0

Rare severe toxicity:

Clinical indications

Rusthoven JCO 2009 Lee JCO 2009

47/63 36-60 Gy / 3fr

1 pt

-RILD -Liver function decline

68/141 27.7-60 Gy / 6 fr

2 pts

-GI ulceration -GI perforation

Van der Pool Br J Surg 2010

20/31 37.5-45 Gy / 3 fr

2 pts

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