Physics Bucharest 2017

Challenges to be resolved in radiotherapy

Target definition

Proof of concept study

120

GTV

BTV

100

40 Tumour volume (cm 3 ) 60 80

20

0

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22

Patient

~45% volume reduction (p=0.002)

Hafeez et al., Characterisation of tumour boost with diffusion weighted MRI (DW-MRI) to inform biological target volume for radical radiotherapy in muscle invasive bladder cancer (MIBC) NCRI 2015.