Physics Bucharest 2017

Functional imaging to assist volume definition

Advantages- Proposed individualisation • Alternative tracers

• Hypoxic tumour regions demonstrate intrinsic radio-resistance, 64 Cu-ATSM (sub-volume for dose escalation)

• ‘dose painting by contours’

• PET based volume is treated to a specified dose level while keeping the mean dose to the remaining target constant

• ‘dose painting by numbers’ • an inhomogeneous dose across the target volume is informed by the PET voxel intensity