Physics Bucharest 2017

First clinical results following adaptive RT in NSCLC

I N=104 (N)SCLC patients, 52 ART with PTV margin 4mm for primary tumor, 52 bone match with 10mm PTV margin I Follow-up CT scans in three-monthly intervals I Median follow-up 16 months (3-35 months), treatment adaptation in 12/52 ART-patients I Locoregional recurrence 35% ART, 53% in non-ART ( p =0.05), marginal recurrence in 1 versus 4 patients

I Overall survival: 10 versus 8 months I Grade ≥ 2 pneumonitis: 18% versus 22% ( p =0.6)

Tvilum et al ., Acta Oncologica 2015