Physics Bucharest 2017

Relative Biological Effectiveness (RBE) - particles

RBE-weighted Dose (Gy (RBE)) = Absorbed Dose (Gy) x RBE

D (Co-60; 250kV) D (p-ions)

RBE =

Biological effect (cell inactivation)

RBE is the ratio of the dose of photons, e.g., 60 Co-rays or linear accelerator X- rays, relative to that of protons/ions required to produce a defined biologic response

RBE is a function of LET, Z, cell type, dose, endpoint