Physics Bucharest 2017

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Model-based approach

Selection

STEP 1: NTCP model

Multivariable NTCP-models STEP 2: Individual dose comparison Dose reduction (  Dose ): relevant DVH parameters? STEP 3: Estimate NTCP reduction (ΔNTCP) Translate  Dose to  NTCP

Validation

STEP 4: Validation External validation NTCP-model with new technology

Langendijk , et al . Radiother Oncol 2013; Courtesy of Hans Langendijk, UMC Groningen

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