Physics Bucharest 2017

Model-based selection

Decision support system

70%

Radiotherapy alone

60%

Concomitant chemoradiation

70%

Dmean supraglottic = 10Gy Dmean supraglottic = 20Gy Dmean supraglottic = 30Gy Dmean supraglottic = 40Gy Dmean supraglottic = 50Gy Dmean supraglottic = 60Gy Dmean supraglottic = 70Gy 70%

50%

60%

70%

Radiotherapyalone

40%

50%

60%

Concomitant chemoradiation

Dmean supraglottic = 10Gy Dmean supraglottic = 20Gy Dmean supraglottic = 30Gy Dmean supraglottic = 40Gy Dmean supraglottic = 50Gy Dmean supraglottic = 60Gy Dmean supraglottic = 70Gy

40%

30%

50%

NTCP(%)

60%

30%

20%

40%

NTCP(%)

50%

20%

10%

30%

IMRT

40%

NTCP(%)

10%

0%

20%

0 10 20 30 40 50 60 70 Mean dose superior PCM 0% 0 10 20 30 40 50 60 70 Mean dose PCM superius 10% 20% 30% NTCP(%)

0%

10%

0 10 20 30 40 50 60 70 Mean dose superior PCM

0%

0 10 20 30 40 50 60 70 Mean dose PCM superius

ΔNTCP criteria fulfilled ?

P

YES

IMPT

Courtesy of Hans Langendijk, UMC Groningen