PowerPoint Presentation

Rational treatment selection for Merkel Cell Carcinoma (MCC): A randomised phase III multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary MCC with an observational study for patients ineligible for the randomised trial (Rational-MCC)

Phase III trial, study end 2024 Intervention – two-arm randomisation 1:1

INCLUSION CRITERIA: Patients newly presenting with histologically proven MCC and who are being considered for radical loco-regional control

PRIMARY OBJECTIVE: -LRC SECONDARY OBJECTIVES: -PFS and OS

OUTLINE: Radical surgery vs. radical XRT as the first definitive treatment Skin SMDT in equipoise