Quantitative Methods 2017

Association between tumour characteristics, cancer treatments, and subsequent rate of MCEs in women irradiated for breast cancer

2p

Rate ratio*

Cancer treatments

Type of surgery

Mastectomy

1.0†

0.2

Breast-conserving

0.9

Adj hormonal therapy No

1.0 1.2 1.0 0.7 1.0 0.9 1.0 1.2 1.0 1.0 1.0 0.8

0.1

Yes

Adj chemotherapy

No

0.1

Yes

Ovarian ablation

No

0.5

Yes

Tumour characteristics Nodal status

Negative Positive

0.06

Tumour size

< 2 cm 2-5 cm

1.0

Tumour location

Outer quadrants Inner quadrants

0.2

*Estimated by logistic regression after stratification for country, age at cancer diagnosis, year of cancer diagnosis, and years from cancer diagnosis to first subsequent MCE (cases) or index date (controls) † Category listed first is baseline

FMB

NEJM 2013; 368:987-98