Quantitative Methods 2017

2 Hazard ratio A 2.5 3

1.5

1

0

5

10

15

20

25

30

35

40

Increase in mean heart dose (Gy)

p-value c) Hazard ratio B 0·001 0·4 0·7 0·02 0·8 0·4 2 2.5 3

Final model b)

Full model

p-value C)

Hazard ratio (95% CI)

Hazard ratio (95% CI)

Mean dose to the heart [Gy]

1·015 (1·006–1·024)

1·015 (1·006–1·024)

0·001

Mean dose to the left internal carotid artery [Gy]

1·007 (0·991–1·023)

*

Mean dose to the right internal carotid artery [Gy] Cumulative dose of anthracycline [50 mg/m 2 ]

0·997 (0·983–1·012)

*

1·074 (1·013–1·138)

1·077 (1·021–1·137)

0·006

Cumulative dose of vinblastine [mg/m 2 ] Cumulative dose of vincristine [mg/m 2 ]

1·000 (0·998–1·002)

*

0·989 (0·966–1·013)

*

1.5

1

0

100

200

300

400

500

Increase in cumulative dose of anthracyclines (mg/m 2 )