Quantitative Methods 2017

Endpoints of treatment efficacy

Endpoint

Definition of event

Local control

No evidence of disease at the primary site (T-position)

Local failure rate

Recurrence in T-position

Locoregional control

No evidence of disease in T- and N-position

(Overall) survival

Death irrespective of cause

Cause-specific survival

Death of cancer

Disease-free survival

Any recurrence or death from any cause, whichever comes first

Local recurrence-free survival

Local recurrence or death from any cause, whichever comes first

Disease-free rate

Any recurrence

Local relapse free rate

Local recurrence

Bentzen et al. Radiotherapy Oncology 1998; 46: 5-18