Quantitative Methods 2017

Clinical relevance

One factor model 1

Multi- factor model 2

Independent variables

Wilks' Lambda

p-value

Wilks' Lambda

p-value

RTOG late toxicity RTOG xerostomia

0.897 0.923 0.798 0.922 0.934 0.956 0.973 0.950 0.956 0.915 0.965

p<0.001 p=0.019 p<0.001 p=0.018

0.948 0.965 0.859 0.974 0.971 0.984 0.973 0.940 0.983 0.969 0.945

p=0.003

RTOG mucosal RTOG swallowing RTOG subcutanuous

ns

p<0.001

ns ns ns

RTOG larynx RTOG skin

ns ns

Other variables Sex

ns

ns

Age

p<0.001

p=0.001

UICC stage

ns

ns ns

Primary tumor site Treatment modality

p=0.022

ns

p=0.002

Langendijk et al. J Clin Oncol 2008;26:3770-3776