Quantitative Methods 2017

Example

Acute toxicity

Late toxicity

0% 20% 40% 60% 80% 100%

CHART Observed/expected

Conventional Observed/expected

Toxicity

Superficial and deep mucosal ulceration

0.64

1.53

CHART results in significant increase in acute mucosal reactions but protects against late mucosal reactions: Acute toxicity is NO surrogate marker for late mucosal reactions

CHART

Conventional

No mucositis

Patchy mucositis

Confluent mucositis

Dische et al. Radiotherapy Oncology 1997; 44: 123-136