Quantitative Methods 2017

Risks of non-compliance

Number with major adverse impact

Number of patients

Enrolment bracket

Percent

1-4 (26 centers)

57

17

29.8%

5-9 (22 centers)

130

28

21.5%

10-19 (22 centers)

279

33

11.8%

> 20 (11 centers)

352

19

5.4%

Better few centres with many patients, than many centres with few patients

Peters, et al. J Clin Oncol 2010; 28: 2996-3001